kPNI (Clinical Psycho-Neuro-Immunology)
As a kPNI therapist in my practice in Amsterdam, I combine clinical Psycho-Neuro-Immunology with mesology and orthomolecular therapy. In doing so, I examine the connections between, among other things, the nervous system, the immune system, hormones, metabolism, lifestyle, and nutrition. On this page, you can read about what kPNI entails and how I apply this approach in my practice.
kPNI
kPNI stands for Clinical Psycho-Neuro-Immunology. It is an integrative approach that examines the connections between various systems and processes in the body, such as the psyche, the nervous system, the immune system, the endocrine system, and metabolism. Factors such as nutrition, exercise, sleep, and stress are also taken into account.
How kPNI approaches the body as a whole
In kPNI, the body is viewed as a cohesive whole. The nervous system, immune system, endocrine system, metabolism, and intestines do not function in isolation from one another but constantly influence each other. As a result, a long-term disruption within one system may be linked to changes in other systems.
kPNI is not a separate form of therapy, but a way of looking at health issues from various perspectives. This approach can take into account factors such as nutrition, exercise, sleep, stress, breathing, and the circadian rhythm. Based on the individual’s personal situation, we assess which factors may be at play and where support might be helpful.
When warranted, additional tests may be ordered, such as blood, stool, or saliva tests. These can provide additional information and help further identify certain factors.
Hormetic stimuli within kPNI
Within the kPNI framework, hormetic stimuli can be used to support the body’s adaptive capacity. Hormesis refers to the phenomenon whereby a brief, controlled stimulus can activate various cellular adaptive and protective mechanisms.
Examples of such stimuli include physical exercise, temporary exposure to cold or heat, and certain forms of fasting. Adequate recovery time between these stimuli is also important: a hormetic stimulus must be appropriate for the individual’s resilience and health status.
One of the mechanisms that may play a role here is Nrf2. Nrf2 is a transcription factor involved in the regulation of genes that play a role in, among other things, antioxidant defense, cellular protection, and the response to oxidative stress.
In my practice, I therefore look not only at individual symptoms, but also at factors such as nutrition, exercise, sleep, stress, circadian rhythm, and recovery. The appropriate interventions vary from person to person.
Testimonials
Marina M
Jasmine M
“My experiences with Dafna were life changing, I say that with no exaggeration. Her work has helped me better understand my body and implement some big lifestyle changes that are needed for me to reduce my stress levels, and heal my nervous system. From her ability to hold space, to her treatments (Mesology and supplementation), she sees the body as a whole, rather than a sum of its parts. I cannot express how grateful I am to have had the opportunity to share my health history with someone who truly listens. This is becoming increasingly uncommon in the health and wellness industry.”
Tamara S
“Thanks to Dafna, I am a lot fitter now than I have been in years. The combination of Mesology and her orthomolecular knowledge have such great value. My liver was found to be very weakened and with her help, supplements and changes in my diet advised by her, I can now do more than 2x as much in a day/in a week as I could a year ago. I have a chronic diagnosis, so am very grateful to her for this result.”
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Hillegomstraat 12-14
1058LS Amsterdam
Schalkburgerstraat 17
1092JW Amsterdam
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